CLOCK Proteins

Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.

Also Known As:

CLOCK Protein; Circadian Locomotor Output Cycles Kaput Proteins

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Acetyltransferases: 1040
        Lysine Acetyltransferases: 125
        Histone Acetyltransferases: 655
        CLOCK Proteins: 57
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Basic Helix-Loop-Helix Transcription Factors: 510
      - CLOCK Proteins: 57
  - DNA-Binding Proteins: 2009
    - Basic Helix-Loop-Helix Transcription Factors: 510
      - CLOCK Proteins: 57
  - Intracellular Signaling Peptides and Proteins: 32
    - Circadian Rhythm Signaling Peptides and Proteins
      - CLOCK Proteins: 57
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Circadian Rhythm Signaling Peptides and Proteins
      - CLOCK Proteins: 57

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Disease

Drug/Important Bio-Agent (IBA)